The couple had two sets of identical twins at a Houston hospital. All four are boys and met their two-year-old big brother for the first time on Monday.
The newborns were delivered via cesarean section at 32 weeks, weighing between two pounds,15 ounces and three pounds, 15 ounces.
Manuel and Tressa Montalvo say they did not use any fertility treatments.
Doctors say the babies are all progressing well.