Hanover County fire officials said they were called to 11300 block of Washington Highway just after 9:20 p.m.
When firefighters arrived at the building, which used to be leased be Fox Auto Service, they said no one was inside the building.
The fire was marked under control just after 10:15 p.m., but crews were still spraying water on hot spots as of 11:30 p.m.
The building was being used to store trucks belonging to the Kona Ice Shaving Company. Firefighters said four trucks were a total loss.
The fire marshal is investigating what sparked the blaze.